Brown Dwarfs in the Pleiades Cluster. III. A deep IZ survey

We present the results of a deep CCD-based IZ photometric survey of a ~1 sq. deg area in the central region of the Pleiades Galactic open cluster. The magnitude coverage of our survey (from I~17.5 down to 22) allows us to detect substellar candidates with masses between 0.075 and 0.03 Msol. Details of the photometric reduction and selection criteria are given. Finder charts prepared from the I-band images are provided.Comment: 11 pages with 8 figures, 4 of them are finder charts given in gif format. Accepted for publication in A&AS. Also available at http://www.iac.es/publicaciones/preprints.htm

New Brown Dwarfs in the Pleiades Cluster

We present intermediate and low resolution optical spectroscopy (650-915 nm) of seven faint, very red objects (20 > I >= 17.8, I-Z >= 0.5) discovered in a CCD-based IZ survey covering an area of 1 sq. deg in the central region of the Pleiades open cluster. The observed spectra show that these objects are very cool dwarfs, having spectral types in the range M6-M9. Five out of the seven objects can be considered as Pleiades members on the basis of their radial velocities, Halpha emission and other gravity sensitive atomic features like the NaI doublet at 818.3 and 819.5 nm. According to current evolutionary models the masses of these new objects range from roughly 80 MJup for the hottest in the sample down to 45 MJup for Roque 4, the coolest and faintest confirmed member. These observations prove that the cloud fragmentation process extends well into the brown dwarf realm, suggesting a rise in the initial mass function below the substellar limit.Comment: 16 pages, 2 figures, aasms4 macro in LateX. 1997 ApJ Letters, accepte

Membership and Multiplicity among Very Low-Mass Stars and Brown Dwarfs in the Pleiades Cluster

We present near-infrared photometry and optical spectroscopy of very low-mass stars and brown dwarf candidates in the Pleiades open cluster. The membership status of these objects is assessed. Eight objects out of 45 appear to be non-members. A search for companions among 34 very low-mass Pleiades members (M$\le$0.09 M$_\odot$) in high-spatial resolution images obtained with the Hubble Space Telescope and the adaptive optics system of the Canada-France-Hawaii telescope produced no resolved binaries with separations larger than 0.2 arcsec (a ~ 27 AU; P ~ 444 years). Nevertheless, we find evidence for a binary sequence in the color-magnitude diagrams, in agreement with the results of Steele & Jameson (1995) for higher mass stars. We compare the multiplicity statistics of the Pleiades very low-mass stars and brown dwarfs with that of G and K-type main sequence stars in the solar neighborhood (Duquennoy & Mayor 1991). We find that there is some evidence for a deficiency of wide binary systems (separation >27 AU) among the Pleiades very low-mass members. We briefly discuss how this result can fit with current scenarios of brown dwarf formation. We correct the Pleiades substellar mass function for the contamination of cluster non-members found in this work. We find a contamination level of 33% among the brown dwarf candidates identified by Bouvier et al. (1998). Assuming a power law IMF across the substellar boundary, we find a slope dN/dM ~ M^{-0.53}, implying that the number of objects per mass bin is still rising but the contribution to the total mass of the cluster is declining in the brown dwarf regime.Comment: to be published in The Astrophysical Journa

A Search for Very Low-mass Stars and Brown Dwarfs in the Young sigma Orionis Cluster

We present a CCD-based photometric survey covering 870 sq. arcmin in a young stellar cluster around the young multiple star sigma Orionis. Our survey limiting R, I, and Z magnitudes are 23.2, 21.8, and 21.0, respectively. From our colour-magnitude diagrams, we have selected 49 faint objects, which smoothly extrapolate the photometric sequence defined by more massive known members. Adopting the currently accepted age interval of 2-10 Myr for the Orion 1b association and considering recent evolutionary models, our objects may span a mass range from 0.1 down to 0.02 Msun, well within the substellar regime. Follow-up low-resolution optical spectroscopy (635-920 nm) for eight of our candidates (I=16-19.5) shows that they have spectral types M6-M8.5 which are consistent with the expectations for true members. Compared with their Pleiades counterparts of similar types, Halpha emission is generally stronger, while NaI and KI absorption lines appear weaker, as expected for lower surface gravities and younger ages. Additionally, TiO bands and in particular VO bands appear clearly enhanced in our candidate with the latest spectral type, SOri 45 (M8.5, I=19.5), compared to objects of similar types in older clusters and the field. We have estimated the mass of this candidate at only 0.020-0.040 Msun, hence it is one of the least massive brown dwarfs yet discovered. We also discuss in this paper the potential role of deuterium as a tracer of both substellar nature and age in very young clusters.Comment: Accepted for publication in ApJ Main Journal. 32 pages of text and tables + 9 pages of figures. Figures 3a and 3b (gif format) provided separatel

The UKIDSS-2MASS Proper Motion Survey I: Ultracool dwarfs from UKIDSS DR4

The UKIRT Infrared Deep Sky Survey (UKIDSS) is the first of a new generation of infrared surveys. Here we combine the data from two UKIDSS components, the Large Area Survey (LAS) and the Galactic Cluster Survey (GCS), with 2MASS data to produce an infrared proper motion survey for low mass stars and brown dwarfs. In total we detect 267 low mass stars and brown dwarfs with significant proper motions. We recover all ten known single L dwarfs and the one known T dwarf above the 2MASS detection limit in our LAS survey area and identify eight additional new candidate L dwarfs. We also find one new candidate L dwarf in our GCS sample. Our sample also contains objects from eleven potential common proper motion binaries. Finally we test our proper motions and find that while the LAS objects have proper motions consistent with absolute proper motions, the GCS stars may have proper motions which are significantly under-estimated. This is due possibly to the bulk motion of some of the local astrometric reference stars used in the proper motion determination.Comment: Accepted for publication in MNRA

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Multiple sclerosis is a common disease of the central nervous system in which the interplay between inflammatory and neurodegenerative processes typically results in intermittent neurological disturbance followed by progressive accumulation of disability. Epidemiological studies have shown that genetic factors are primarily responsible for the substantially increased frequency of the disease seen in the relatives of affected individuals, and systematic attempts to identify linkage in multiplex families have confirmed that variation within the major histocompatibility complex (MHC) exerts the greatest individual effect on risk. Modestly powered genome-wide association studies (GWAS) have enabled more than 20 additional risk loci to be identified and have shown that multiple variants exerting modest individual effects have a key role in disease susceptibility. Most of the genetic architecture underlying susceptibility to the disease remains to be defined and is anticipated to require the analysis of sample sizes that are beyond the numbers currently available to individual research groups. In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, we have replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci. Within the MHC we have refined the identity of the HLA-DRB1 risk alleles and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes are significantly overrepresented among those mapping close to the identified loci and particularly implicate T-helper-cell differentiation in the pathogenesis of multiple sclerosis

A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis

Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but measurable effects. We propose a “candidate interactome” (i.e. a group of genes whose products are known to physically interact with environmental factors that may be relevant for disease pathogenesis) analysis of genome-wide association data in multiple sclerosis. We looked for statistical enrichment of associations among interactomes that, at the current state of knowledge, may be representative of gene-environment interactions of potential, uncertain or unlikely relevance for multiple sclerosis pathogenesis: Epstein-Barr virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, cytomegalovirus, HHV8-Kaposi sarcoma, H1N1-influenza, JC virus, human innate immunity interactome for type I interferon, autoimmune regulator, vitamin D receptor, aryl hydrocarbon receptor and a panel of proteins targeted by 70 innate immune-modulating viral open reading frames from 30 viral species. Interactomes were either obtained from the literature or were manually curated. The P values of all single nucleotide polymorphism mapping to a given interactome were obtained from the last genome-wide association study of the International Multiple Sclerosis Genetics Consortium & the Wellcome Trust Case Control Consortium, 2. The interaction between genotype and Epstein Barr virus emerges as relevant for multiple sclerosis etiology. However, in line with recent data on the coexistence of common and unique strategies used by viruses to perturb the human molecular system, also other viruses have a similar potential, though probably less relevant in epidemiological terms